CD9 suppresses human extravillous trophoblast invasion
نویسندگان
چکیده
منابع مشابه
Extravillous Trophoblast Migration and Invasion Assay.
Extravillous trophoblast (EVT) migration and invasion through the decidualized endometrium is essential to successful placentation. SGHPL-4 cells, an EVT cell line derived from first trimester placenta, is a widely used model of cytotrophoblast differentiation into an invasive phenotype. Here we describe a quantitative cell migration assay that can be modified to also measure cell invasion. SGH...
متن کاملVitamin D promotes human extravillous trophoblast invasion in vitro.
INTRODUCTION Incomplete human extravillous trophoblast (EVT) invasion of the decidua and maternal spiral arteries is characteristic of pre-eclampsia, a condition linked to low maternal vitamin D status. It is hypothesized that dysregulated vitamin D action in uteroplacental tissues disrupts EVT invasion leading to malplacentation. METHODS This study assessed the effects of the active vitamin ...
متن کاملAdhesion molecules in human trophoblast - a review. II. extravillous trophoblast.
At the tips of anchoring villi, cytotrophoblast (CTB) proliferation leads to a process of multilayering in which cells lose their attachment to the villous basement membrane and develop into columns, within which they adhere to one another using desmosomes, with associated intermediate filament bundles. Non-desmosomal cadherins, tight junction proteins and other adhesion molecules are also pres...
متن کاملMTA3 Regulates Extravillous Trophoblast Invasion Through NuRD Complex
Extravillous trophoblast (EVT) invasion is required for remodeling uterine tertiary arteries and placenta development during pregnancy. Compromised EVT invasion may contribute to the pathology of placenta-related diseases. Metastasis -associated protein 3 (MTA3) is one of the subunits of nucleosome remodeling and deacetylation (NuRD) complex that represses transcription in a histone deacetylase...
متن کاملPLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration
Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a successful pregnancy, and dysregulation of this process may lead to malignant pregnancy outcomes, such as preeclampsia. Finding specific markers for different types of trophoblast cells is essential for understanding trophoblast differentiation. Here, we report that placenta-specific protein 8 (PLAC8) is s...
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ژورنال
عنوان ژورنال: Placenta
سال: 2016
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2016.09.014